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Acylation reagents for GC - Anhydrides

Macherey-Nagel GmbH & Co. KG (15131)

Acylation reagents for GC - Anhydrides
For improved volatility, better thermal stability or low limit of detection in gas chromatography prerequisite: quantitative, rapid and reproducible formation of only on derivative halogen atoms introduced by derivatisation (e.g. trifluoroacetates) allow specific detection (ECD) with the advantage of high sensitivity elution order and fragmentation patterns in MS can be influenced by a specific derivatisation.
Reagents for silylation - alkylation (methylation) - acylation are available.
Acylation with fluorinated acid anhydrides can be used for alcohols, phenols, carboxylic acids, amines, amino acids and steroids forming volatile, stable derivatives suited for FID as well as for ECD detection.

by-products of acylation with anhydrides: corresponding acids
excess reagent and the acid formed have to be removed

Heptafluorobutyric acid anhydride (HFBA)
m.w. 410.06, Bp 106 - 107°C (760mm Hg),
C3F7 - CO - O - CO - C3F7
density d20°/4° = 1.665

PN	Manuf. PN	Supplier	Capacity~ml	Description	PK	General	Price
4001480	701110.201	Macherey-Nagel GmbH & Co. KG	1	HFBA	20	Dangerous substance	Inquire
4001479	701110.110	Macherey-Nagel GmbH & Co. KG	10	HFBA	1		202.94 EU
4001481	701110.510	Macherey-Nagel GmbH & Co. KG	10	HFBA	5		823.53 EU

Acylation reagents for GC - Bisacylamides

Macherey-Nagel GmbH & Co. KG (15132)

Acylation reagents for GC - Bisacylamides
For improved volatility, better thermal stability or low limit of detection in gas chromatography prerequisite: quantitative, rapid and reproducible formation of only on derivative halogen atoms introduced by derivatisation (e.g. trifluoroacetates) allow specific detection (ECD) with the advantage of high sensitivity elution order and fragmentation patterns in MS can be influenced by a specific derivatisation.
Reagents for silylation - alkylation (methylation) - acylation are available.
Acylation with fluorinated acid amides is recommended for alcohols, primary and secondary amines as well as for thiols under mild, neutral conditions. MBTFA also forms very volatile derivatives with carbohydrates.

by-products: corresponding neutral acylamides, which can be easily removed due to their high volatility; because of neutral conditions and favourable chromatographic properties often removal of the bisacylamide is not necessary. Thus sample preparation is much more convenient.

MBTFA / MBHFBA
N-methyl-bis(trifluoroacetamide) MBTFA
m.w. 223.08, Bp 123 - 124°C (760mm Hg), density d20°/4° = 1.55,
CF3 - CO - N(CH3) - CO - CF3

PN	Manuf. PN	Supplier	Capacity~ml	Description	PK	General	Price
7510796	701410.110	Macherey-Nagel GmbH & Co. KG	10	MBTFA	1	Dangerous substance	Inquire
6228605	701410.510	Macherey-Nagel GmbH & Co. KG	10	MBTFA	5		1014.71 EU
7401143	701410.201	Macherey-Nagel GmbH & Co. KG	1	MBTFA	20		519.12 EU

Acylation kit

Macherey-Nagel GmbH & Co. KG (15128)

Acylation kit
For improved volatility, better thermal stability or low limit of detection in gas chromatography prerequisite: quantitative, rapid and reproducible formation of only on derivative halogen atoms introduced by derivatisation (e.g. trifluoroacetates) allow specific detection (ECD) with the advantage of high sensitivity elution order and fragmentation patterns in MS can be influenced by a specific derivatisation.
Reagents for silylation - alkylation (methylation) - acylation are available.
Which is the proper reagent for acylation?
Test kit for determination of the optimum acylation.

PN	Manuf. PN	Supplier		Content	PK									General	Price	Quantity	Status	Add
6207118	701950	Macherey-Nagel GmbH & Co. KG		2 x 1 ml each for MBTFA , TFAA, MBHFBA	1										233.82 EU